Located on Main Street’s historic Museum Row in the heart of Bourbon Country, 21c Museum Hotel Louisville is the world’s first museum hotel. Blending contemporary art and historic architecture, this unique hotel experience offers an inspiring space for culture, creativity, and comfort.
Make yourself at home. Preserving the history of former bourbon & tobacco warehouses with all the comforts of fine design, 21c Louisville’s guest rooms offer a comfortable place to land after a long day of adventure.
Revival: Digging Into Yesterday, Planting Tomorrow
Presenting 70 works of art by 47 artists from all over the world, illuminating how looking at the past clarifies the present and reimagines the future.
Fallen Fruit: The Practices of Everyday Life
Fallen Fruit’s immersion into the people and places that shape community reveals a universal, defining aspect of the human condition: hunger.
Asleep In The Cyclone
New York-based artists Jonah Freeman and Justin Lowe have created a completely immersive art-experience-turned-guestroom.
David (inspired by Michelangelo)
Serkan Özkaya’s replicated work — made of fiberglass and spray-painted gold —addresses the issue of value, both economic and artistic.
Dine & Drink
Proof on Main is a culinary love-letter to the Ohio River Valley, led by Kentucky native and Executive Chef Cody Stone.
proof on main
One of Louisville’s most iconic dining institutions, Proof on Main’s menus showcase a unique and well-traveled approach to southern and Appalachian-inspired cuisine. The Proof on Main lounge is also home to the 21c Selects Private Barrel Program, and is consistently ranked one of the best bourbon bars in the country.
Whether you are hosting corporate meetings, milestone events, or a spectacular Louisville wedding, 21c combines versatile event spaces with crafted creativity to ensure your gathering is unforgettable down to the last detail.
Explore our menu of massage treatments that promote relaxation, stress reduction, and overall wellness. Indulge in a massage and sweat it out in the sauna or steam room before or after your treatment.
Enjoy the very best of the bluegrass when you explore Louisville’s local hot-spots. From bourbon and baseball bats to history and horse-racing, 21c Museum Hotel Louisville’s stellar downtown location is just steps away from all the action. 21c Louisville is in the center of Louisville Museum Row, steps from the Louisville Slugger Museum & Factory, KMAC Contemporary Art Museum, Kentucky Science Center, Muhammad Ali Center, Frazier History Museum, and the Louisville Riverwalk. We are a hotel near Humana Headquarters, Churchill Downs, Fourth Street Live! and convenient for those visiting YUM! Brand and UPS Worldport.
